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Hypersensitivity negative side effects have actually hardly ever included pruritus, rash, urticaria, angioedema, bronchospasm, and also anaphylaxis. A minimum of one case of cutaneous leukocytoclastic vasculitis has also been stated. [Ref]





A 34-year-old man with a record of excessive weight experienced cutaneous leukocytoclastic vasculitis coincident with orlistat therapy. He determined to take orlistat (120 mg just before dishes) as medical therapy for obesity. Seventy-two hrs after the beginning of this therapy, he experienced arthralgias and also myalgias. He likewise noted the presence of maculopapular sores in quickly enhancing numbers in his better extremities. A skin biopsy revealed leukocytoclastic vasculitis influencing venules as well as veins. Orlistat was terminated as well as bed rest and also nonsteroidal anti-inflammatory medications were suggested. Complying with commencement of this procedure, a rapid enhancement of the cutaneous sores was acquired. [Ref]





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Respiratory negative side effects have included influenza, top breathing infection, lesser respiratory infection, and nose, neck and also ear signs. [Ref]





Bone and joint negative effects have actually included pain in the back, discomfort in the reduced extremities, arthritis, myalgia, joint ailment, and tendonitis. [Ref]





Nerves side effects have actually included headache as well as lightheadedness. Postmarketing negative effects have actually consisted of reports of convulsions in individuals dealt with concomitantly with orlistat and also antiepileptic drugs. [Ref]





Dermatologic negative effects have included rash as well as dry skin. Unusual situations of bullous eruptions have been reported during postmarketing encounter. [Ref]

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